Patients & Caregivers / Clinical Trials/Research Studies

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Clinical Trials/Research Studies - Recruiting


EXPEDITION 3 Clinical Trial

Description: This study will test the idea that the investigational medication solanezumab will slow the cognitive and functional decline of Alzheimer's Disease (AD) as compared with placebo in participants with mild AD.

Study Length: Approximately 18 months

Study Requirements
  • Individuals with a diagnosis of mild Alzheimer’s disease
  • Ages 55 – 90
  • A study partner who will accompany the participant to all clinic visits
Contact:
Carolyn Rickard at 412-692-2707 mishlercj@upmc.edu or
MaryAnn Oakley at 412-692-2721 or oakleym@upmc.edu




Learning New Fact Knowledge through Reinforcement

Description: This is a behavioral study investigating how people acquire “factual” knowledge using feedback and repetition. The data gathered through this project is expected to enhance investigators’ understanding of how different memory systems interact and how people might change their strategies to learn optimally. Participants will be asked to work through a series of talks on a computer. (No computer knowledge is necessary.)

Study Length: 1 visit of approx. 2 hours

Study Requirements: Control participants or participants with a diagnosis of Alzheimer disease.

Contact: MaryAnn Oakley at 412-692-2721 or oakleym@upmc.edu




Medication Study for the Treatment of Agitation in Moderate to Severe Alzheimer's Disease

Description: The purpose of this study is to determine whether an investigational medication (ELND005) is effective for reducing behaviors in people with moderate to severe Alzheimer's disease who have agitation/aggression.

Study Length: 12 Weeks

Study Requirements
  • Diagnosis of moderate to severe Alzheimer's disease with behavior problems/agitation.
  • A study partner who will accompany the participant to all clinic visits.
Contact: MaryAnn Oakley at 412-692-2721 or oakleym@upmc.edu



Objective Evaluation of Family Caregiving Study

Description: The goal of this study is to learn how family caregivers deal with dementia-related behavior and how they respond to suggestions for handling these situations at home. Participants will be asked to wear a video device at home to capture daily interactions with their family member with dementia.

Study Length: 3-4 months

Study Requirements
  • Family caregiver age 21 or older who lives with and provides care to a person with moderate to severe dementia
  • Person age 50 or older with moderate or severe dementia whose behavior is difficult for the caregiver
  • Willing to engage in all study activities at home and by phone
Contact: MaryAnn Oakley at 412-692-2721 or oakleym@upmc.edu



The Recall Study (Retaining Cognition while Avoiding Late-Life Depression)

Description: This research project will test whether Problem Solving Therapy (PST) is successful in preventing major depression for those living with mild cognitive impairments. We will also examine the effect of modest exercise on mood.

Study Requirements: Individuals 60 years and older with a diagnosis of Mild cognitive impairment.

Study length: 8-12 weeks of PST sessions and follow up visits at 3 month intervals for 12 months.

Contact: MaryAnn Oakley at 412-692-2721 or oakleym@upmc.edu