Patients & Caregivers / Clinical Trials/Research Studies

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Clinical Trials/Research Studies - Recruiting


Noble Study

Description: This is a clinical study to evaluate an investigational drug in mild to moderate Alzheimer's disease. The investigational drug may work by protecting brain cells which could result in improved memory. adcs.org

Study Length: 14 months

Study Requirements
  • 55-85 years of age
  • Diagnosis of Alzheimer's disease (Mild-Moderate)
  • A study partner who will accompany the participant to all clinic visits
  • Weight of no more than 220lbs
  • Taking certain memory medication(s) for 6 months
Contact:
Thomas Baumgartner at 412-692-2716 or baumgartnertc@upmc.edu or
MaryAnn Oakley at 412-692-2721 or oakleym@upmc.edu



A4 Study

Description: The Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease Trial, or A4 Study, is among a new generation of clinical trials being developed to test therapies that might prevent, or at least delay the onset of, Alzheimer's disease in cognitively normal people who may be at risk as evidenced by a PET scan. a4study.org

Study Length: 3 years

Study Requirements
  • 65 to 85 years of age
  • Normal thinking and memory abilities
  • Have a study partner with whom you have contact at least once a week who can answer questions about you once a year (contact may be in person or by phone) willing and able to receive IV infusions of the investigational treatment (solanezumab) or a placebo every 4 weeks for 3 years
Contact:
MaryAnn Oakley at 412-692-2721 or oakleym@upmc.edu or
Katy Zorich at 412-692-2719 or orchowskik3@upmc.edu



STARBEAM Study (Lundbeck)

Description: The primary objective of this study is to establish the efficacy of an investigational medication (Lu AE58054) as adjunctive therapy to Donepezil for symptomatic treatment of patients with mild-moderate Alzheimer's disease.

Study Length: 7 months

Study Requirements
  • Individuals age 50 or older with mild–moderate Alzheimer's disease
  • Not currently taking memantine
  • Stable treatment with donepezil
  • A study partner who will accompany the participant to all clinic visits
Contact:
MaryAnn Oakley at 412-692-2721 or oakleym@upmc.edu



AMBAR Study

Description: The purpose of this study is to determine whether short-term followed by long-term, low-volume plasma exchange (a process of blood filtering) is able to modify Alzheimer Disease patient's cognitive, functional, and behavioral symptoms.

Study Length: 14 months (Six weekly plasmapheresis sessions followed by 12 monthly plasmapheresis sessions)

Study Requirements
  • 55-85 years of age
  • Individuals with a diagnosis of mild to moderate Alzheimer's disease
  • A study partner who will accompany the participant to all clinic visits
Contact:
Donna Simpson, 412-692-2717 or simpsondm@upmc.edu or
MaryAnn Oakley at 412-692-2721 or oakleym@upmc.edu



Communication about Type 2 Diabetes Treatment in Older Adults with Memory Problems

Description: This study is investigating how diabetes treatment goals and medication decisions are made for older adults with both Type 2 Diabetes Mellitus (T2DM) and memory problems. We will be interviewing 12 informal (unpaid) caregivers of older adults with both T2DM and memory problems.

Study Length: Participation involves one telephone interview that takes 30-60 minutes. Participants will be compensated $40 for completing the interview.

Study Requirements
You may be eligible if you:
  • provide informal care to a spouse, relative, or friend who is 65 years of age or older and has both T2DM and memory problems
  • attend medical appointments with the person for whom you care
  • are age 18 or older
For more information, please contact: Loren Schleiden at 724-766-0361 or ljs24@pitt.edu