Researchers / Call for Proposals
Introduction: One of the research missions of the Alzheimer Disease Research Center (ADRC) at the University of Pittsburgh is to fund pilot grants to stimulate new and innovative research relevant to Alzheimer’s disease. Types of research can range from basic science to psychosocial in methodology, with particular attention given to novel approaches. Proposed research may involve humans, other animals or in vitro studies. The investigator is responsible for obtaining appropriate Institutional Review Board or Animal Care and Use Committee approval for the proposal. The patient population, clinical, and neuropathological databases of the ADRC are available resources for approved proposals. Additional resources include the database from the National Alzheimer Coordinating Center (NACC). Priority will be given to studies which have the highest chance of leading to subsequent external peer reviewed funding. Applications must clearly state the significance and innovation of the proposed research to Alzheimer’s disease or related disorders.
Criteria for Review: The following will be considered in evaluating the merit of a proposal:
Eligibility: Applicants must be full-time faculty and post-doctoral fellows of the University of Pittsburgh. Post-doctoral fellows must have a letter of support from their mentor and department chair indicating they will be at the University through 2015. Previous recipients of ADRC seed monies are not eligible.
Budget Limitations: Direct cost budgets up to $25,000 will be considered. There is no allowance for travel, tuition, publication costs or major equipment. Please contact the ADRC Administrator, Leslie Dunn, MPH (firstname.lastname@example.org) with budget questions.
The proposal should consist of the following sections:
Please provide a list of three prospective reviewers. The specific aims and hypotheses are limited to one page and the research strategy is limited to a total of six single-spaced pages based on PHS 398 (Rev. 06/09) format and guidelines. Abstract, budget, biographical sketches and resources and environment sections should be on the standard forms for PHS grants (08/12 version).
Send application materials:
Via e-mail to email@example.com (Send Word documents. No PDFs please.)
Also send hard copy of the application to:
Leslie Dunn, MPH
Alzheimer Disease Research Center
4-West UPMC Montefiore Hospital
200 Lothrop Street
Pittsburgh, PA 15213
For further information: Interested applicants should discuss potential submission with:
Center Director, Oscar L. Lopez, M.D., firstname.lastname@example.org
Center Co-Director, William E. Klunk, M.D., Ph.D., email@example.com or
Center Administrator, Leslie Dunn, MPH, (412) 692-2731, firstname.lastname@example.org
University of Pittsburgh, School of medicine
Alzheimer Disease Research Center
4-West UPMC Montefiore, 200 Lothrop Street
Pittsburgh, PA 15213
Pilot Studies for the 2014-2015 Grant Year (PDF) »
The competing renewal for the Alzheimer’s Disease Research Center (ADRC) will be due at NIA in June 2014. We anticipate that the instructions for our renewal will be similar to those used in the competitive renewals for the Centers renewing this year (2013). NIA has specified that all center renewals include two to three research proposals for the five years of the renewal. Preliminary budgets can be in the $125,000 to $150,000 range. Subsequent year direct costs can include a 3% per year increase.
Projects should be similar to small R01 grants or subprojects of program project grants. At least one of the proposals must utilize patients or patient samples from the ADRC Clinical Core or neuropathology resources, but dementia-related basic science studies are encouraged as well. In keeping with the mission of training and encouraging new researchers in the field of AD, at least one of the projects must be lead by a junior investigator who has not yet had NIH R01 grant support. Thus, projects from junior investigators have a higher probability of being included in our ADRC competitive renewal submission.
According to the current RFA, the principal aim of the ADRCs should be to enhance the performance of innovative research on AD and related topics, including research that may lead to potential disease-modifying therapy or behavioral or other symptom treatments. Centers are requested to concentrate their attention on better defining normal aging and the transition from normal aging to mild cognitive impairment (MCI) to the earliest stages of dementia, whether AD itself or other related dementias associated with aging. Centers should incorporate contemporary biochemical/molecular techniques and pursue research, when feasible, in genomics, epigenomics, proteomics and metabolomics. The central focus of projects may be translational research, clinical – pathological research, basic research or a combination.
The ADRC, therefore, requests proposals of 1-2 pages from the research community that would include a brief statement of the purpose and underlying rationale, specific aims and hypotheses, and a summary of preliminary data that would strengthen the proposal. If applicable, indicate how the proposal would utilize the clinical resources of the Center. Attach a list of potential Co-Principal Investigators or Co-Investigators. The ADRC Executive Committee, in consultation with the ADRC Internal and External Advisory Committees, will select proposals for inclusion in the ADRC submission. For any proposal not selected for inclusion in the ADRC renewal, the ADRC faculty and staff will work with the principal investigator to develop a proposal for appropriate funding utilizing the ADRC for resources, as an R01 or other appropriate funding modality.
The 1-2 page proposals should be submitted on paper or electronically to ADRC Administrator, Leslie Dunn, at email@example.com by September 20, 2013. Notification of proposals accepted for submission will be done by end of November, 2013. Please contact Leslie Dunn or ADRC Director, Dr. Oscar Lopez (firstname.lastname@example.org) or ADRC Co-Director, Dr. Willam Klunk, (email@example.com) with questions or further information.
Research Projects for the Competing Renewal due June, 2014 (PDF) »
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